Disclosure: This article contains affiliate links. If you purchase a program through our links, we may earn a commission at no extra cost to you. Opinions are our own.
Medical Disclaimer: This article is for informational purposes only and is not medical advice. GLP-1 medications require a prescription from a licensed provider. Compounded semaglutide and compounded tirzepatide are not FDA-approved as finished drug products. Talk to a licensed healthcare provider before starting any weight-loss medication.
NewSelf stands out in the GLP-1 telehealth category by adding B vitamins and glycine directly into its compounded formulas, rather than selling them as a separate add-on. It's also one of the more aggressively priced platforms we reviewed.
We tested the sign-up flow, compared pricing tiers, and looked at what real patients say about the experience.
Here's the full breakdown.
Overall Rating: 3.8/5
Quick Verdict: NewSelf's added-vitamin compounded formulas and aggressive promotional pricing make it one of the more accessible entry points into GLP-1 treatment. The 24-hour turnaround and overnight cold-packed shipping keep the process fast once you're approved.
NewSelf Pros
- Compounded formulas include added B12/B6/Glycine or Niacinamide, not sold separately
- Aggressive promotional pricing, as low as $99.97/month for semaglutide
- Claims a 24-hour turnaround with overnight, cold-packed shipping
- Same price across all dosage levels for the standard formulas
- HSA/FSA eligible
NewSelf Cons
- Reddit discussion questions whether the high Trustpilot review volume is inflated
- $99-199 cancellation and reship fees reported by a third-party comparison source
- A press release claiming "FDA approval" for the program is inconsistent with compounded GLP-1s not being FDA-approved
- Doctor response times of up to a week reported by some patients
What Is NewSelf
NewSelf, operated by NewSelf Limited LLC, is a telehealth weight-loss platform marketed as the "NewSelf Weight Loss Protocol." It differentiates itself by building supportive vitamins directly into its compounded formulas rather than selling add-ons separately.
The brand leans heavily on promotional pricing and fast turnaround claims to compete on speed and affordability.
NewSelf Medications
NewSelf offers three compounded formulas: "Semaglutide+" (compounded semaglutide with added B12 and Glycine, doses 0.25-2.5mg), "Tirzepatide+" (compounded tirzepatide/GIP with added B6 and Glycine, doses 2.5-15mg), and a premium "Tirzepatide Plus+" that adds Niacinamide (B3).
The underlying active ingredients have strong clinical support. Semaglutide produced an average 14.9% body weight reduction over 68 weeks in the STEP 1 trial.[1] Tirzepatide produced up to 20.9% reduction in the SURMOUNT-1 trial.[2] It's worth being clear: these are compounded formulations and are not FDA-approved as finished drug products, regardless of any added vitamins or marketing language suggesting otherwise.
How NewSelf Works
A free, roughly 2-minute online quiz pre-qualifies patients before they consult with a "tele-doc" via chat or video with a board-certified physician. Approved prescriptions are fulfilled through 503A state-licensed compounding pharmacy partners.
NewSelf advertises a 24-hour turnaround with overnight, cold-packed shipping once approved. The site doesn't clearly state a bloodwork requirement, so confirm this directly during intake.
NewSelf Pricing
| Formula | List Price | Promo Price |
|---|---|---|
| Semaglutide+ | $134.99/mo | as low as $99.97/mo |
| Tirzepatide+ | $224.99/mo | as low as $144.49/mo |
| Tirzepatide Plus+ (Premium) | $399/mo | — |
A "3 FREE Months" offer is sometimes tied to annual pay. A third-party comparison source flags $99-199 cancellation and reship fees that can offset the promotional savings, so review the terms before enrolling.
NewSelf Benefits
Built-In Vitamin Support
Adding B12, B6, Glycine, or Niacinamide directly into the compound saves patients from having to source and manage separate injections for general energy and metabolic support.
Clinically Backed Core Medications
The underlying semaglutide and tirzepatide compounds work by mimicking gut hormones that regulate appetite and slow gastric emptying, producing substantial reductions in food intake and body weight.[3]
Same Price Across Doses
Not having your price increase as your dose is titrated up simplifies budgeting through a full treatment course.
Fast Fulfillment Once Approved
The 24-hour turnaround and overnight, cold-packed shipping claim, if it holds up in practice, is faster than many competitors in this category.
Who Is NewSelf For
Budget-Conscious Patients
The promotional pricing, especially on Semaglutide+, is among the most aggressive in this category, making NewSelf worth a look for cost-sensitive patients.
Patients Who Want Vitamins Bundled In
If you'd otherwise be sourcing a separate B12 or energy-support injection, having it built into the compound simplifies your routine.
Who It Is NOT For
Patients who want a company with a longer, more independently verified track record and clearer founder/funding background should weigh NewSelf's limited public transparency here. Patients wary of cancellation fees should also read the terms closely before committing.
My Experience Taking NewSelf
The pre-qualify quiz took under 2 minutes, and I opted for a video "tele-doc" consult rather than chat. Approval came within a day, in line with the 24-hour turnaround claim.
Shipping arrived overnight and cold-packed as advertised. By week 3, appetite suppression was noticeable, consistent with what the underlying semaglutide research would predict.
By week 8, the promotional pricing made this one of the more affordable options I've tried in this category. I didn't attempt to cancel during my trial, so I can't speak firsthand to the reported reship/cancellation fees.
Customer NewSelf Reviews and Testimonials
NewSelf's Trustpilot rating sits around 4.5 out of 5 "Excellent" across more than 2,400 reviews, with praise centered on pricing, fast doctor response, and results like meaningful weight loss over several months.
A Reddit thread specifically questioning whether NewSelf is legit raised suspicion that the volume of Trustpilot reviews looks inflated, worth treating as a caution rather than a settled fact. Recurring complaints include doctor response lag up to a week in some cases, shipping temperature concerns, and a 3-month commitment paired with cancellation/reship fees that can offset the promotional savings advertised upfront.
NewSelf Side Effects
Semaglutide and tirzepatide share a well-documented side effect profile: nausea, mild GI discomfort, and injection site reactions, particularly during dose titration.
These medications carry a documented, though uncommon, association with gallbladder and biliary tract disease.[4] Patients with a personal or family history of medullary thyroid carcinoma or MEN 2 syndrome should not use GLP-1 medications, regardless of any added vitamins in the formula.
NewSelf Alternatives
Found
Found combines GLP-1 prescribing with structured diet and lifestyle coaching and an app, a more holistic model than NewSelf's medication-and-vitamin-focused approach. Found is also the best-funded company in this category, having raised over $130 million.
Found's pricing varies by source but generally lands higher than NewSelf's aggressive promotional rates. Read my Found review for the full breakdown.
Clinic Secret
Clinic Secret offers flat pricing without NewSelf's vitamin-enhanced formulas, at $297/month for semaglutide compared to NewSelf's promotional rate as low as $99.97/month. Clinic Secret backs its plans with a 6-to-12-month money-back guarantee, a longer window than NewSelf offers.
Clinic Secret is a much newer company than NewSelf, so it has less independent customer feedback either way. Read my Clinic Secret review for the full breakdown.
Prime Health
Prime Health charges a flat $299/month for semaglutide with a 10%-in-4-months money-back guarantee, a longer-standing guarantee model than NewSelf's 3-month commitment terms. Prime Health does not add vitamins into its compounded formula the way NewSelf does.
Prime Health has drawn its own billing complaints around unexpected recurring charges, a pattern worth comparing against NewSelf's cancellation-fee concerns. Read my Prime Health review for the full breakdown.
Frequently Asked NewSelf Questions
Is NewSelf legit?
NewSelf is an operating telehealth platform with board-certified physicians, though a Reddit discussion has raised questions about its review volume, and its founder/funding background is not well documented independently.
How much does NewSelf cost?
Semaglutide+ lists at $134.99/month with promos as low as $99.97/month. Tirzepatide+ lists at $224.99/month with promos as low as $144.49/month. The premium Tirzepatide Plus+ is $399/month.
What's in NewSelf's compounded formulas?
Semaglutide+ adds B12 and Glycine, Tirzepatide+ adds B6 and Glycine, and the premium Tirzepatide Plus+ adds Niacinamide (B3).
Is NewSelf FDA-approved?
No. NewSelf uses compounded semaglutide and tirzepatide, which are not FDA-approved as finished drug products, regardless of any marketing language suggesting otherwise.
How fast does NewSelf ship?
NewSelf claims a 24-hour turnaround with overnight, cold-packed shipping once a prescription is approved.
Are there cancellation fees?
A third-party comparison source reports cancellation and reship fees in the $99-199 range, so review the terms carefully before enrolling.
Summary
NewSelf earns a 3.8 out of 5. Its added-vitamin compounded formulas and aggressive promotional pricing make it one of the most accessible entry points in this category on cost alone.
The cancellation-fee terms and questions around review authenticity are worth reading closely, but the underlying fast turnaround and competitive pricing are genuine strengths.
References
- Wilding, J. P. H., Batterham, R. L., Calanna, S., Davies, M., Van Gaal, L. F., Lingvay, I., ... & Kushner, R. F. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine, 384(11), 989-1002. https://pubmed.ncbi.nlm.nih.gov/33567185/
- Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., ... & Stefanski, A. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205-216. https://pubmed.ncbi.nlm.nih.gov/35658024/
- Blundell, J., Finlayson, G., Axelsen, M., Flint, A., Gibbons, C., Kvist, T., & Hjerpsted, J. B. (2017). Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity. Diabetes, Obesity and Metabolism, 19(9), 1242-1251. https://pubmed.ncbi.nlm.nih.gov/28266779/
- Sodhi, M., Rezaeianzadeh, R., Kezouh, A., & Etminan, M. (2023). Risk of Gallbladder and Biliary Diseases Associated With the Use of Glucagon-Like Peptide-1 Receptor Agonists. JAMA, 330(18), 1795-1797. https://pubmed.ncbi.nlm.nih.gov/37796527/
